Mathematical
Diseases-theraReCliNostic-Research Institute
Shaping a Better Health One Equation at a Time
Welcome to MDtRI, where interdisciplinary research meets mathematical modeling to address global health challenges.
Welcome to MDtRI, where interdisciplinary research meets mathematical modeling to address global health challenges.
Innovative Research
At MDtRI, we are committed to exploring new concepts and ideas to improve human health. Our research is highly collaborative. Learn more about our work below.
RiVela (Riemann inspiration Visualization
& enriched clusters lanscape)
Harshita Sinha, “No child chooses the mutations they are born with, yet those mutations can determine the course of an entire life. That truth has always stayed with me. It is what compelled me to become part of the solution--to push toward discoveries that might one day save a life. This drive led me to pursue an independent research project on Group 3 Medulloblastoma, one of the most aggressive and devastating pediatric brain cancers worldwide. Knowing that my work could contribute, even in a small way, to future therapies continues to fuel my purpose. That passion also opened doors to opportunities I never imagined--opportunities that were incredibly challenging, highly selective, and profoundly rewarding. I was honored to earn 2nd place at the exceptionally competitive Washington State Science and Engineering Fair (WSSEF) and 4th place at the highly selective Washington HOSA State Research Poster Competition. Receiving the prestigious Seattle Children’s Research Institute – Cancer and Blood Disorders Center Award, presented by the Ben Towne Center at the Central Sound Region Science and Engineering Fair, was a moment of immense pride. One of my most unforgettable experiences was having my work accepted for presentation at the renowned Annual High School Neuroscience Forum at Stanford, a nationally recognized platform for rising young researchers. But none of these achievements were reached alone. I am deeply grateful to Dr. Lokendra Thakur at MDtRI, whose exceptional mentorship shaped not only my research but my growth as a young scientist. Being part of the MDtRI team has been an invaluable privilege that strengthened my resolve to continue contributing to biomedical research. I am equally thankful to Ms. Cullison at Lake Stevens High School, who believed in me even during the moments when I questioned myself. And to my parents--my unwavering foundation through every setback, and breakthrough--these accomplishments are as much theirs as they are mine.
'I’m grateful for every step of this journey--and even more grateful that it’s only the beginning.' "
Updates
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Recognized among the top innovators in the Washington State USA, Harshita Sinha earned 2nd place overall at WSSEF (out of 594 projects), advancing to the International Science and Engineering Fair.
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Our LOI application for the Alzheimer's Association Research Grant For All (AARGA) 2026 is approved.
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Our abstract submission has been accepted for a poster presentation at AAIC 2026, London, UK.
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Congratulations to our higher school researcher, Harshita Sinha, for (i) winning the prestigious Seattle Children's Research Institute Cancer and Blood Cancer Award, (ii) securing 4th place in the Washington state-level competition, and (iii) research presentation acceptance, Annual High School Neuroscience Forum at Stanford.
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Our Letter Of Intent is invited to submit a full Proposal for Phase II of the Nuttall Women’s Health grant process.
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Our iEL team lead and PI, was invited by an AAIC 2026 Scientific Program Committee to serve as an Abstract Reviewer (2026).
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Our Letter Of Intent application for the Alzheimer's Association Research Grant For All (AARGA) is approved.
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Publications: we have successfully published five preprints (Dg-Dig-SSNs (AMR diagnostics), Sheaf-ML, ci-fGBD, Microbeyt, and MAP-PRS).
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Successfully launched the Biomedical Research Training & Skills Development Program (BRT&SDP) to foster next-generation scientific talent.
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Participated at the Alzheimer’s Association International Conference (AAIC) in Toronto, Canada.
Biomedical Research Training & Skills Development Program
Unlock Your Potential in Biomedical Research!
Gain hands-on training, expert mentorship, and real-world experience to build skills, critical thinking, and confidence.
Apply now! Selection is by the Training & Skills Development Committee, and no fees apply for selected candidates.
Note: Applications are reviewed on a rolling basis in three-month cycles (Jan–Mar, Apr–Jun, Jul–Sep, Oct–Dec).
Bridging Education
&
Biomedical Research
Excellence
Bushra Malik
University of Toronto, Canada
👉 "During my training at MDtRI, I gained hands-on experience in advanced computational biology, data integration, and research methodology. I not only learned how to apply innovative clustering and analytical techniques to complex, multimodal datasets, but also developed critical skills in problem-solving, collaboration, and scientific communication. This training provided me with the foundation and confidence to transition into the MDtRI research team, where I was able to contribute meaningfully to projects at the intersection of mathematics, computation, and biomedical science— leading to a published research paper. The program did a great job in helping transform my academic knowledge into practical expertise!"
Harshita Sinha
Seatle, Washington, USA
👉 “This training program taught me that 80% of research is developing the right question and planning how to interpret data, while experimentation comes last.
Through the 4-week training, I gained vital skills in breaking down the research process and choosing the right data for each project.
I’m grateful to join the MDtRI research team and collaborate with high-level researchers.”
Harshita Sinha's Achievements
Funding:
Collaboration:
